Background: The Ready-Made Garments industry in Dhaka, Bangladesh, is a key contributor to the national economy and employs a large number of operational-level workers. Despite its economic importance, issues related to employee job satisfaction remain a major concern. 
Objective: This study examines the influence of key Human Resource Management (HRM) practices on job satisfaction among operational-level employees in the garments sector. 
Methods: A quantitative research design was employed, collecting data through structured questionnaires from 386 employees across major industrial areas. Simple random sampling ensured every eligible employee had an equal chance of participation. Data were analyzed using SPSS, applying multiple regression techniques to explore the relationships between HRM practices and job satisfaction. 
Results: Findings reveal that all five HRM practices have a positive and significant impact on job satisfaction. These results indicate that engaging employees in decision-making, providing meaningful development opportunities, conducting fair performance evaluations, ensuring employment stability, and offering appropriate rewards enhance job satisfaction. 
Implications and Future Study: The study offers practical recommendations for HR managers and policymakers to improve HR strategies tailored to employee needs. Furthermore, it contributes to the literature by providing empirical evidence from a developing country context, specifically within Bangladesh’s labor-intensive garment sector. The study also suggests conducting future research across diverse industry contexts.