Objective: Main goal of this learn is to know molecular mechanism that links miRNA-155 to the pathophysiology of Graves' disease, as this would help in revealing innovative paths and methods for diagnosing and treating the disease, as this disease is considered an autoimmune problem that affects the thyroid gland and leads to other complications such as eye and skin disorders. 
Subjects and Methods: The study included 200 samples, 100 of which were from infected people and the other from healthy people for comparison purposes. Their ages ranged between 20-40 years from visitors to Al-Diwaniyah Teaching Hospital in the period between March to September 2025. 5 ml of blood was collected from all participants, 1 ml of each sample was used in the polymerase chain reaction to detect miRNA155 using PCR technology. The remaining 4 ml of each sample was used to measure interleukin levels by enzyme-linked immunosorbent assay and other biochemical tests in this study. 
Results: The yield of the statistical analysis disclose that there were significant statistical variable amidst two groups regarding the level of miRNA-155 (p=0.05). While the difference was clear regarding the level of interleukin-7, as it was high in the serum of patients compared to healthy people (p=0.001), while interleukin-4 was lessen in serum of patients compared to control (p=0.001), As for TRAb test, the statistical result was highly influential between the two groups (p=0.001), and the statistical differences were clear and noticeable for other biochemical tests. 
Conclusion: Based on the outputs we obtained, represented by the results, there is a possibility of using miRNA 155 as a diagnostic tool to predict Graves’ disease.