Lipid droplets (LDs) have emerged as pivotal organelles implicated in cancer metastasis, offering novel therapeutic targets for intervention. This review comprehensively examines the mechanisms by which LDs contribute to metastasis, focusing on their biogenesis, interaction with metastatic pathways, and influence on the tumor microenvironment. Recent advances in LD-targeted therapies, including pharmacological interventions, genetic and molecular approaches, and nanotechnology-based delivery systems, are discussed. Challenges such as biological complexity, therapeutic delivery barriers, and potential resistance mechanisms are also addressed. Future directions highlight emerging technologies, opportunities for translational research, and the importance of interdisciplinary collaborations in advancing LD research. By elucidating these aspects, this review aims to contribute to the development of effective strategies to disrupt LD-mediated metastasis and improve cancer treatment outcomes.