The integration of full-stack Enterprise Resource Planning (ERP) systems in healthcare organizations has emerged as a transformative approach to streamlining operations, enhancing clinical decision-making, and optimizing financial management. This paper explores the design, implementation, and impact of integrated ERP systems that combine clinical, financial, and reporting modules to improve healthcare efficiency. Through a comprehensive review of existing literature and current practices, the study identifies the key components of such systems, including electronic health records (EHR), patient management, billing, and financial reporting. It further examines the challenges and opportunities associated with the integration of clinical and financial data, focusing on the importance of interoperability with existing healthcare infrastructure and the adoption of modern integration techniques such as APIs and microservices. The paper also highlights best practices for system testing, deployment, and user training to ensure successful implementation. Ultimately, the findings suggest that integrated ERP systems contribute significantly to reducing errors, optimizing resource allocation, enhancing real-time data access, and improving patient care outcomes. The study concludes with recommendations for future research directions, particularly in the areas of artificial intelligence, data privacy, and interoperability, to further enhance the capabilities and adoption of ERP systems in healthcare.